Full guide to Oregon vs USC: How to watch, weather, odds, history and more

The USC Trojans find themselves squarely in the College Football Playoff race, and with one final ranked opponent left on the regular-season schedule in the No. 7 ranked Oregon Ducks, the top-15 Trojans will have everything to play for when the ball is kicked off in Eugene this weekend.

When and Where is USC vs Oregon

Matchup: No. 15 USC (8-2, 6-1 B1G) vs No. 7 Oregon (9-1, 6-1 B1G)

Date: Saturday, Nov. 22, 2025

Kick: 12:30 p.m. PT (3:30 p.m. ET)

Where: Autzen Stadium, Eugene, Oregon

TV: CBS

Streaming: FuboTV 

Radio: ESPN LA 710

Rankings for USC and Oregon

With the newest release of the CFP rankings, the Trojans will enter this game at No. 15, while Oregon climbed one spot to No. 7. Both teams have appeared in each of the committee’s rankings so far this season. This matchup will be USC’s fifth game against a top-25 opponent and their highest-ranked opponent to date.

Betting Odds for USC vs. Oregon

USC enters the matchup as a 9.5-point under dogs and is listed at +295 on the moneyline, with the over/under set at 59.5. Fans should check their preferred sportsbook for the latest odds and updates.

Weather Forecast for USC vs. Oregon

Game-time conditions in Eugene are expected to be cool, with temperatures near 51°F, partly cloudy skies, light winds, and only a slight 5% chance of rain.

USC and Oregon Previous Results

USC 26, Iowa 21 (Nov. 15): USC stormed back in the second half, pitching a 16–0 shutout in the second half to defeat No. 21 Iowa in a rainy Coliseum atmosphere.

Oregon 42, Minnesota 13 (Nov.14): Oregon handled Minnesota comfortably at home, with Dante Moore leading the offense by throwing for 300 yards and two touchdowns.

USC vs. Oregon Series History

The Trojans and Ducks are no strangers, as the former Pac-12 rivals are set to renew their rivalry as conference opponents for the first time as members of the Big Ten. USC holds the all-time advantage with a 38-23-2 record, but Oregon has enjoyed recent success, winning seven of the last ten meetings. The Trojans’ most recent victory over the Ducks came in 2016.

Key Storylines and Matchup Notes for USC and Oregon

• Oregon marks USC’s fifth matchup against a top-25 opponent this season. The Trojans are currently 2–2 in those games, and securing a third ranked win would put them firmly in the driver’s seat for a College Football Playoff spot.

• USC has not allowed an opponent to score more than three points in the second half across its last three games. However, the Trojan defense is also known for slow starts, and putting together a full four quarters of high-level play will be essential if they hope to pull off the upset.

• Oregon is 5–1 at home this season, while USC sits at 2–2 on the road. If the Trojans hope to keep themselves in the College Football Playoff conversation, they’ll need to buck that trend in Eugene this weekend.