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USC will host Northwestern for the first time as conference opponents, with the game coming on a short week. The Wildcats travel to Los Angeles for a primetime Friday night matchup on FOX, entering the contest with a 5–3 record this season..
When and Where is Northwestern vs USC
Matchup: No. 19 USC (6-2, 4-1 B1G) vs Northwestern (5-2, 3-2 B1G)
Date: Friday, Nov. 7, 2025
Kick: 6:00 p.m. PT (9:00 p.m. ET)
Where: United Airlines Field at L.A. Memorial Coliseum, Los Angeles Coliseum
TV: FOX
Streaming: FuboTV
Radio: ESPN LA 710
Rankings for USC and Northwestern
USC enters the weekend ranked 19th in the College Football Playoff rankings, while Northwestern remains unranked by the committee.
Betting Odds for USC vs. Northwestern
USC enters the matchup as a 14.5-point favorite and is listed at -550 on the moneyline, with the over/under set at 50.5. Fans should check their preferred sportsbook for the latest odds and updates.
Weather Forecast for USC vs. Northwestern
Game-time conditions in Los Angeles are expected to be ideal, with temperatures around 70°F, clear skies, and calm winds.
USC and Northwestern Previous Results
- USC 21, Nebraska 17 (Nov.1 ): Running back King Miller rushed for 129 and a touchdown to help lead a second half comeback victory for the Trojans.
- Northwestern 21, Nebraska 28 (Oct.25): Wildcats' running back Caleb Komolafe rushed for two touchdowns as Nebraska was able to thwart a late comeback from the Wildcats.
USC vs. Northwestern Series History
USC holds a perfect 5-0 record against Northwestern, with their most recent meeting coming in the 1996 Rose Bowl which resulted in a 41-32 victory for the Trojans.
Key Storylines and Matchup Notes for USC and Northwestern
- The Trojans face a quick turnaround with this matchup taking place on a Friday night, while Northwestern enters the contest well-rested following a bye week after their road loss to Nebraska two weeks ago.
- USC remains unbeaten at home this season with a 4-0 record and will look to extend that success, as Northwestern has struggled away from Illinois with a 1-2 mark on the road.
- Trojans running back King Miller comes into the game averaging 7.8 yards per carry, the second-highest mark in the conference.