Full guide to Louisiana vs USC: How to watch, weather, odds, history and more

The USC Trojans are set to host Louisiana in their final non-conference matchup of the season before shifting their focus to Big Ten play next week and a cross-country trip to Rutgers.

Off to a dominant 2-0 start, the Trojans have outscored their opponents by a combined margin of 72-26 and look to maintain their momentum heading into the heart of their schedule.

When and Where is USC vs Louisiana

Matchup: No. 14 USC (1-0, 0-0 B1G) vs Louisiana (1-0, 0-0 Sun Belt)

Date: Saturday, Sep. 12th, 2026

Kick: 8:00 p.m. PT (11:00 p.m. ET)

Where: United Airlines Field at L.A. Memorial Coliseum, Los Angeles Coliseum

TV: Big Ten Network

Streaming: FuboTV 

Radio: ESPN LA 710

Rankings for USC and Louisiana

Despite a dominant 2-0 start to the season, the Trojans remain ranked No. 14 in the latest AP poll. They will look to improve their standing as they face an unranked Louisiana squad this weekend.

Betting Odds for USC vs. Louisiana

USC enters the matchup as a -30.5 point favorite with the over/under set at 59.5. Fans should check their preferred sportsbook for the latest odds and updates.

Betting odds are subject to change

Weather Forecast for USC vs. Louisiana

Game-time conditions in Los Angeles are expected to be clear, with temperatures around 74°F, clear skies and winds up to 4 mph.

USC and Louisiana Previous Results

• The Trojans are coming off a commanding 39-0 shutout victory against Fresno State, a game defined by a suffocating defensive performance that included two safeties. Offensively, quarterback Jayden Maiava eclipsed 300 passing yards, while Trent Mosley continued his hot streak by registering another impressive 100-yard performance.

• The Ragin' Cajuns enter this matchup coming off a 38-7 victory over Lamar, a performance highlighted by a potent ground game that saw the team punch in five rushing touchdowns. Louisiana will look to carry that offensive momentum into the Coliseum as they prepare for a significantly tougher test against the Trojans.

USC vs. Louisiana Series History

This is the first time that USC and Louisiana will meegt on the football field.

Key Storylines and Matchup Notes for USC and Louisiana

• USC closes out its non-conference slate against Louisiana this weekend before shifting focus to the most demanding stretch of their schedule. With the Big Ten gauntlet looming, this matchup serves as a vital final tune-up for a Trojans team that faces one of the toughest paths in the country for the remainder of the season.

• Jayden Maiava aims to sustain his Heisman-caliber start to the season, having already recorded more touchdowns than incompletions through the first two games.

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