Both Notre Dame and USC enter the game with a record of 4-2, and each would love to earn their fifth win of the season against a rival.
The Irish are looking to retain possession of the Jeweled Shillelagh with their second consecutive victory over the Trojans.
USC has a five game winning streak in South Bend, and has won nine of the last 11 games.
Brian Kelly is 8-3 in games following a bye week, but only 2-1 in such games as head coach of Notre Dame. His lone loss after a bye week with the Irish came to the Trojans in 2011.
USC may get Marqise Lee back, which would give Cody Kessler another big weapon.
Thus far, the lone common opponent USC and Notre Dame have played is the Arizona State Sun Devils.
The Sun Devils trounced the Trojans in Tempe to the tune of 62-41, and were then defeated by the Irish, 37-34, the following week.
Notre Dame quarterback Tommy Rees has had his fair share of struggles since he’s regained control of the Irish offense.
If USC can stick to their keys, they should remain in position to walk away victorious.
Albeit as the interim head coach, the Ed Orgeron era got off to a booming start with a win over Arizona, and with a win in South Bend, he may earn a longer look from Pat Haden for the permanent position.